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While butyrate primarily acts as an HDAC inhibitor, its metabolism to acetyl-CoA can also stimulate Histone acetylation / Histone acetyltransferase (HAT) activity. This dual role supports the acetylation process by both inhibiting deacetylation and providing the necessary substrate for acetylation
Butyrate's role in histone acetylation has implications for cancer research, as it can modulate the epigenetic landscape to suppress cancer cell growth while pro…