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Gnotobiotic mice models
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An attractive strategy to standardize the microbiota is the use of gnotobiotic mice, i.e., mice with known microbial colonization status, which can be generated by introducing well-characterized microbial communities into germ-free animals
In gnotobiotic mice, fiber-deprived gut microbiota targets host mucin glycans as an energy source
Transplantation of feces from [cytolysi…
References (Sources)
- Defined mouse microbiota: An “evolving” tool
- Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans
- Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice
- Leveraging diet to engineer the gut microbiome
- Mining the human gut microbiota for effector strains that shape the immune system.
- The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice
- The Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins