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Aryl Hydrocarbon Receptor (AhR) has both pro- and anti-tumor roles depending on the context and immune cell subset (1). It acts as a sensor of Tryptophan metabolism products and is a potent modulator of immunity (2). Additionally, AhR is a cell type-specific transcription factor responsive to a wide variety of small molecules in the environment (3, 4).
References:
(1)
(2)
(3) Qiu et al. 2012 Immunity. 36: 92-104
(4)
see also:
AhR signal transduction pathway
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