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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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AuthorsReferences (Sources)

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AhR signal transduction pathway

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Contents

AhR signal transduction pathway

The Aryl Hydrocarbon Receptor (AhR) is a ligand-activated transcription factor that plays a crucial role in regulating gene expression in response to both environmental and endogenous stimuli, known as ligands. These ligands can include 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD), polycyclic aromatic hydrocarbons (PAHs), or endogenous compounds such as kynurenine, natural plant flavonoids, polyphenols, an…

References (Sources)

Association of the Ah receptor with the 90-kDa heat shock protein
Perdew 1988 The Journal of Biological Chemistry 263(27): 13802-13805
Definition of a minimal domain of the dioxin receptor that is associated with Hsp90 and maintains wild type ligand binding affinity and specificity
Coumailleau et al. 1995 The Journal of Biological Chemistry 270(42): 25291-25300
Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. Evidence that the dioxin receptor functionally belongs to a subclass of nuclear receptors which require hsp90 both for ligand binding activity and repression of intrinsic DNA binding activity
Pongratz et al. 1992 The Journal of Biological Chemistry 267(19): 13728-13734
Evidence that the co-chaperone p23 regulates ligand responsiveness of the dioxin (Aryl hydrocarbon) receptor
Kazlauskas et al. 1999 The Journal of Biological Chemistry 274(19): 13519-13524
Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity
Meyer et al. 1998 Molecular and Cellular Biology 18(2): 978-988
Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor
Whitelaw et al. 1993 Molecular and Cellular Biology 13(4): 2504-2514
The 90-kDa heat shock protein is essential for Ah receptor signaling in a yeast expression system
Carver et al. 1994 The Journal of Biological Chemistry 269(48): 30109-30112

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