meRfi®-GM
Aryl Hydrocarbon Receptor (AhR) agonists
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
The IDO-dependent kynurenine (Kyn) pathway of tryptophan metabolism is a significant source of endogenous Aryl Hydrocarbon Receptor (AhR) agonists. Through this metabolic pathway, the AhR has the ability to enhance the expression of Indoleamine 2,3-Dioxygenase (IDO) / Indoleamine 2,3-dioxygenase 2 (IDO2), which in turn produces AhR ligands such as Kyn.
AhR agonists activate the receptor. This leads to its …
References (Sources)
- Activation of the arylhydrocarbon receptor causes immunosuppression primarily by modulating dendritic cells
- Detection of aryl hydrocarbon receptor agonists in human samples
- Modulation of Immune Responses by Nutritional Ligands of Aryl Hydrocarbon Receptor
- Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists
- Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor
- The aryl hydrocarbon receptor controls IFN-γ-induced immune checkpoints PD-L1 and IDO via the JAK/STAT pathway in lung adenocarcinoma
- The Aryl Hydrocarbon Receptor Modulates T Follicular Helper Cell Responses to Influenza Virus Infection in Mice