meRfi®-GM
Aryl Hydrocarbon Receptor (AhR) & Ligands
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Contents
Aryl Hydrocarbon Receptor (AhR) ligands are Aryl Hydrocarbon Receptor (AhR) agonists and Aryl Hydrocarbon Receptor (AhR) antagonists or partial agonists/antagonists. The term "AhR ligand" refers broadly to any molecule that binds to the AhR, but the effect of that binding depends on the specific ligand and its mode of action.
Upon ligand binding, Aryl Hydrocarbon Receptor (AhR) translocates into the nucleus and dimerizes with its partner, the [aryl hydrocarbon receptor nuclear translocator (Arnt)](brain://PoQnpNBRt02CSd58rNl-aA/ArylHydrocarbonRecepto…
References (Sources)
- AHR-mediated immunomodulation: the role of altered gene transcription
- Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation
- Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology
- Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation
- External influences on the immune system via activation of the aryl hydrocarbon receptor
- Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction
- Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor