Colonization Resistance & Pathogenic Bacteria

Colonization resistance is one of the primary advantages, referring to the gut's capacity to prevent Pathogenic Bacteria that can cause disease from establishing themselves. Various mechanisms have been identified that affect how the microbiota can offer this resistance. However, these mechanisms are frequently specific to the context and rely on certain strains or species of bacteria.
Spragge et al. 2023 Science 382: eadj3502

The gut microbiota plays a crucial role in preventing Salmonella enterica enterica serovar Typhimurium invasion through a process called colonization resistance (CR)
Caballero-Flores et al. 2023 Nat Rev Microbiol 21: 347-360

Antibiotic use or dietary changes can disrupt gut microbiota, weakening Colonization Resistance and increasing Salmonella enterica enterica Typhimurium / Salmonella Typhiumurium (S. Tm) colonization risk. The bacterium Escherichia coli restricts infections caused by Salmonella Typhimurium following changes in diet and disturbances in the microbiota due to fat in mice.
Barthel et al. 2003 Infect Immun 71: 2839-2858
Wotzka et al. 2019 Nat Microbiol 4: 2164-2174

see also:
Defending & Pathogens / Pathobionts / Pathogenic Bacteria
Dopamine receptor D2 (DRD2)
Escherichia coli (E. coli)
Salmonella enterica enterica serovar Typhimurium
Salmonella Infection / Salmonellosis & Streptomycin