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Cancer cells, regrettably, have devised numerous strategies to avoid being detected and attacked by immune cells. However, recent progress in immunotherapy seeks to combat these evasive maneuvers. This is achieved by eliminating the inhibitory signals on the immune system using targeted drugs known as immune checkpoint inhibitors.
Cancer cells evade immunity by directly inhibiting CD8+ cytotoxic T cells (CD8+ T cells) using immune checkpoint pathways such as [CD279 (Programmed cell death protein 1 (PD-1)](brain://2N14L47SH0m1xi4V4opmLA/Cd279ProgrammedCellDeathProt…