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Caspase recruitment domain-containing protein 8 (CARD8)
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Caspase recruitment domain-containing protein 8 (CARD8) is a protein belonging to the Caspase recruitment domain (CARD)-containing family . This protein is involved in pathways leading to the activation of caspases or nuclear factor kappa-B (NFKB). It has been implicated as a co-regulator of several pro-inflammatory and apoptotic signaling pathways.
Additionally, CARD8 has been shown to negatively regulate NOD2-mediated signaling and inhibit nodosome assembly, which is relevant to its role in inflammatory and infectious processes.
von Kampen et a…