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Responsible for stimulating the digestion of fat and protein by release of digestive enzymes and bile from the pancreas and gallbladder, respectively, and also acts as a hunger suppressant.
Wikipedia
Nutrients stimulate the release of cholecystokinin (CCK) from Enteroendocrine Cells (EEC). It interacts with CCK1R and gastric inhibitory peptide receptors (GIPR) on vagal afferents. Such direct synaptic connections allow for very rapid signaling to the brain, esp. via the area postrema (AP) to the caudal nucleus tractus solitarius (NTS) neurons, which project to higher brain systems and, together with the viscerotropic organization of vagal afferents have the potential to inform the brain what is absorbed at a given location on a second-by-second basis: Distinct vagal-NTS pathways mediate the appetite / reward actions of nutrients in the gut and the hunger / aversive actions of fasting.
Cholecystokinin in sham-feeding rats stops food intake and elicits behavioral signs of satiation and satisfaction.