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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Follicular B Helper T Cells (Tfh)

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T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that play a crucial role in supporting antibody (Ab) responses during respiratory viral infections (
Houser & Lawrence 2022 J Immunol 208: 2319-2330

Role in Immune Responses

Germinal Centers: Tfh cells support germinal centers in producing high-affinity antibody-secreting and memory B cells in mammals and birds
Chen et al. 2022 Trends in Immunology 43: 309

Infection Response: They are essential for protection against C. rodentium infection during the late phase
Bai et al. 2020 J Immunol 204: 2754

Cytokine Production: During infection, Tfh cells produce [Interleukin-21 (IL…

References (Sources)

Follicular helper CD4 T cells (TFH)
Crotty 2011 Annu Rev Immunol 29: 621-663
Review
Follicular Helper T Cells
Vinuesa et al. 2016 Annu Rev Immunol 34: 335-368
Review
Follicular helper T cells are required for systemic autoimmunity
Linterman et al. 2009 J Exp Med 206: 561-576
Pathophysiology of T follicular helper cells in humans and mice
Ueno et al. 2015 Nat Immunol 16: 142-152
Review
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases
Crotty 2019 Immunity 50: 1132-1148
Review
T follicular helper cells and T follicular regulatory cells in rheumatic diseases
Deng et al. 2019 Nat Rev Rheumatol 15: 475-490
Review
The origins, function, and regulation of T follicular helper cells
Ma et al. 2012a J Exp Med 209: 1241-1253
Review

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