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Pain

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Research done in labs has shown that when gut bacteria are removed, it can lower pain caused by chemotherapy and nerve damage. On the other hand, giving certain probiotics to animals has been found to lessen pain sensitivity in cases of long-term pain. This shows a link between an imbalance in gut bacteria and ongoing pain.
Jiang et al. 2025 Cell Host & Microbe 33: 104-118

see also:
Abdominal Pain
Chronic Pain