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We identified the acetate anion as an agonist of human G-Protein Coupled Receptor 43 (GPR43) during routine ligand bank screening in yeast. This activity was confirmed after transient transfection of GPR43 into mammalian cells using Ca 2+ mobilization and [35 S]guanosine 5-O-(3thiotriphosphate) binding assays and by coexpression with GIRK G protein-regulated potassium channels in Xenopus laevis oocytes.
see also:
Agonists & G-Protein Coupled Receptor 43 (GPR43)
[G-Protein Coupled Receptors (GPCRs) & Short-Chain Fatty Acids (SCFAs)](brain://3BsJxSoDg0agaurDRe_mtw/GProteinCoupledRec…