Loading…

Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Butyrate / Butyric acid & G-Protein Coupled Receptor 43 (GPR43)

Welcome to meRfi-GM!

Please register to continue your trial period!

meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.

Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.

Start your free trial and transform your understanding of the gut microbiota today!

The administration of tributyrin, which elevates the concentration of Butyrate / Butyric acid in the colon, also increased the number of neutrophils in the colonic lamina propria, indicating that Butyrate / Butyric acid is a potent booster of neutrophil activity during infection. However, GPR43 and GPR109a, two [G protein–coupled receptors](brain://oVcbpD5M9U-UGTlns8L…

Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation
Le Poul et al. 2003
G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation
Sina et al. 2009 J Immunol. 183(11): 7514–22.
GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3
Zhao et al. 2018d Mucosal Immunol 11: 752-762
The Butyrate-Producing Bacterium Clostridium butyricum Suppresses Clostridioides difficile Infection via Neutrophil- and Antimicrobial Cytokine−Dependent but GPR43/109a-Independent Mechanisms
Hayashi et al. 2021a

5/29/2026