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Cardiac glycoside reductase 2 (Cgr2)
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Contents
Cardiac glycoside reductase 2 (Cgr2) is sufficient to induce IL-17a, a major T helper 17 cell cytokine.
Cardiac glycoside reductase 2 (Cgr2)+ E. lenta depletes putative steroidal glycosides in pure culture; related compounds are negatively associated with human Inflammatory Bowel Disease (IBD) severity.
The cgr2 gene correlates with [Inflammatory Bowel Disease (IBD)](brain://UUceGF1S-UOZoI1lctf08Q/Inflamma…
References (Sources)
- Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins
- Human gut bacterial metabolism drives Th17 activation and colitis
- Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta
- Small molecule inhibitors of RORgt: targeting Th17 cells and other applications