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GenBankAC: CP001726
Eggerthella lenta is associated with autoimmune diseases (see also: Autoimmune Diseases & Gut microbiota)
Human gut Actinobacterium Eggerthella lenta induces intestinal Th17 activation by lifting inhibition of the Th17 transcription factor RAR-related orphan receptor gamma/t (ROR-gamma/t) Isoform 2 through cell- and antigen-independent mechanisms (see also: CD4+ Th17 Cells & Eggerthella lenta)
Eggerthella lenta is enriched in inflammatory bowel disease (IBD) patients and worsens colitis in a rorc gene-dependent manner in mice. E. lenta is associated with human disease and exacerbates colitis in mice
Th17 activation varies across Eggerthella lenta & Strains, attributable to the Cardiac Glycoside Reductase 2 (Cgr2)) enzyme
cgr2+ Eggerthella lenta depletes putative steroidal glycosides in pure culture; related compounds are negatively associated with human IBD severity
Eggerthella lenta is a common member of the human Gut microbiota that has been implicated in autoimmune diseases
Eggerthella lenta belongs to the species in the healthy human gut; the abundance is low: about 0.04% of all species in the healthy human gut
The human gut bacterium Eggerthella lenta manipulates cardiac drug inactivation (see also: Digoxin & Gut Microbiota)