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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Digoxin & Gut microbiota

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Bacterial metabolism can inactivate drugs such as digoxin
Haiser et al. 2014 Gut Microbes 5:233–238
Koppel et al. 2018 eLife 7: e33953

Gut microbiota converts to dihydrodigoxin and dihydrodigoxigenin, showing decreased cardiac activity, by reduction
Li & Jia 2013 Clin. Pharmacol. Ther. 94: 574–581

Digoxin is inactivated by Eggerthella lenta
Haiser et al. 2013 Science 341(6143): 295-8

Eggerthella lenta reduces Cardiac Glycoside Reductase 2 (Cgr2) meaning less reduction of [digoxin](brain://Qrqjnrxa_E…

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Cometabolism of microbes and host: implications for drug metabolism and drug-induced toxicity
Li & Jia 2013 Clin. Pharmacol. Ther. 94: 574–581
Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins
Koppel et al. 2018 eLife 7: e33953
Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics
Haiser et al. 2014 Gut Microbes 5:233–238
Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta
Haiser et al. 2013 Science 341(6143): 295-8

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Digoxin & Gut microbiota

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