PGE2

Prostaglandins (PG) are cytoprotective for gastrointestinal epithelium, possibly because they enhance mucosal repair
Blikslager et al. 1997 J. Clin. Invest. 100: 1928–1933

In contrast to inhibition of crypt regeneration, PGE2 accelerates re-establishment of epithelial barrier
Kim et al. 2017a Gastroenterology 152: 616–630
Miyoshi et al. 2017 EMBO J. 36: 5–24
Jain et al. 2018 Cell Host Microbe 24: 353–363

Prostacyclin and PGE2 synergistically restore barrier function in the ileum by the intracellular Ca 2+ and cAMP signaling-dependent mechanisms
Blikslager et al. 1997 J. Clin. Invest. 100: 1928–1933

see also:
Epithelial Barrier Integrity / Mucosal Barrier Integrity & Gut microbiota