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The emergence of STn is thought to be partly caused by aberrant expression of ST6GalNAc I sialyltransferase (ST6GALNAC1)
Tumour associated STn is associated with poor prognosis and re- sistance to chemotherapy in breast carcinomas, inhibition of DC maturation, DC apoptosis and inhibition of NK activity
Beatson et al. 2015
STn is expressed by more than 80% of human carcinomas
Julien et al., 2012
Anti-cancer vaccine, Theratope, has been designed towards the STn epitope
Julien et al., 2012
STn weakly expressed by fetal and normal adult tissues
Julien et al., 2012
Many anti-STn antibodies have been developed since the mid 80s
Julien et al., 2012
Sialyl-Tn antigen is able to modulate a malignant phenotype inducing a more aggressive cell behavior, such as decreased cell-cell aggregation and increased ECM adhesion, migration and invasion
STn levels are used as a prognostic indicator for cancer aggressiveness and metastatic potential in colorectal, ovarian cancer
sTn antigen was not found in normal tissue except for a weak expression: Leydig cells testis, goblet cells colon, Parietal cells of stomach
Two monoclonal antibodies, TKH1 and TKH2, directed toward the sialosyl-Tn structure