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The emergence of STn is thought to be partly caused by aberrant expression of ST6GalNAc I sialyltransferase (ST6GALNAC1)
Tumour associated STn is associated with poor prognosis and re- sistance to chemotherapy in breast carcinomas, inhibition of DC maturation, DC apoptosis and inhibition of NK activity
Beatson et al. 2015
STn is expressed by more than 80% of human carcinomas
Julien et al., 2012
Anti-cancer vaccine, Theratope, has been designed towards the STn epitope
Julien et al., 2012
STn weakly expressed by fetal and normal adult tissues
Julien et al., 2012
Many anti-STn antibodies have been developed since the mid 80s
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