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Bacteroides appears to be relevant to depressive disorders and mood, but the signal is mixed at the genus level and becomes clearer at the species/strain level: several human datasets report higher Bacteroides in depression, while experimental work shows that some Bacteroides species may worsen depressive-like phenotypes and others may reduce them. They differentially modulate depression-like behavior via gut-brain metabolic signaling.
Li et al. 2026 Commun Biol 9: 247
People with fewer Bacteroides bacteria had a more significant pattern of hyperactivity in the prefrontal cortex, which some researchers have linked to [major depression](brain://soFW1EApfU-…