Capsular Polysaccharides (CPSs)

Understanding the structure and function of Capsular Polysaccharides (CPSs) is important for developing antivirulence strategies and vaccines, as Capsular Polysaccharides (CPSs) are potential targets for antimicrobial interventions
Morelli et al. 2021 ACS Chem Biol. 16(9): 1671-1679
Cai et al. 2023 Microbiol Spectr. 11(5): e0530422

The complete chemical structure of specific Capsular Polysaccharides (CPSs), such as K135 and K106/K112, has been characterized, highlighting the diverse nature of Capsular Polysaccharides (CPSs) in different bacterial strains
Kasimova et al. 2021 Int J Mol Sci. 22(11): 5641
Knirel et al. 2023 Biochemistry (Mosc). 88(2): 202-210

Immune responses to specific bacterial Antigens can be modulated by a diverse set of Capsular Polysaccharides (CPSs).
Hsieh et al. 2020

Capsular Polysaccharides (CPSs) are known to be immunomodulatory
Porter & Martens 2017 Annu. Rev. Microbiol. 71: 349-369).

The best-studied immunoregulatory Capsular Polysaccharides (CPSs) is the polysaccharide A capsule (PSA), which is one of eight Capsular Polysaccharides (CPSs) expressed in [Bacteroides fragilis]
Avci & Kasper 2010 Annu. Rev. Immunol. 28: 107-130

Many bacteria express multiple diverse capsular polysaccharides (CPSs) on their surface for protection against environmental and host factors, including the host immune system
Coyne & Comstock 2008 J. Bacteriol. 190: 736-742

Zwitterionic polysaccharides (ZPSs) from the capsules of some bacteria can activate CD4+ cells.
Cobb et al., 2004

These polysaccharides stimulate the murine humoral immune system to elicit primarily IgM antibody responses. Studies conducted primarily in the mouse have characterized these polymers as T cell-independent antigens.
Tzianabos et al. 2003

see also:
Acquired Immune System / Adaptive Immune System
Zwitterionic polysaccharides (ZPSs)