Arginase II

Arginase II is one of two mammalian arginase isozymes. It is a mitochondrial enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea . Arginase II is a mitochondrial enzyme involved in arginine metabolism , with important roles in regulating nitric oxide production, immune cell function, and inflammation. Its activity is critical in extra-hepatic tissues, especially the kidney, and it is a key player in the resolution of inflammation, making it a significant target for research in immunology, neurology, and cardiovascular medicine
Yin et al. 2020a J Clin Med 9(2): 305
Dowling et al. 2021 Nat Commun 12: 1460
Li et al. 2022 Cell Death Discov 8: 413

Ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose tissue inflammation and improves glucose tolerance in obesity
Huang et al. 2020e Pharmacology 105: 491-504

The role of Arg-II in aging adipose tissue inflammation is not clear
Huang et al. 2020e Pharmacology 105: 491-504

Arg-II promotes Interleukin 6 (IL-6) production in aging adipose tissues through p38mapk in mice
Huang et al. 2020e Pharmacology 105: 491-504

see also:
Aging / Senescence & Inflammation / Inflammatory Diseases
Arginine Metabolism
L-Arginine / Arginine & Immune checkpoint inhibitors (ICIs)