meRfi®-GM
CD4+ Th1 Cells
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Contents
Phenotypic (constitutively) markers: CD4 +
Stimulating factors: Interleukin-12 (IL-12) , Interleukin-18 (IL-18)
Effector molecules: Interleukin-2 (IL-2) , Interferon Gamma (IFN-g) , Lymphotoxin alfa (LT alfa)
They provide help to B cells for antibody production
Principal function of CD4+ Th1 Cells is to activate macrophages through cytokines (e.g., IFN-gamma) to ingest and kill Microbes / Microorganism and tumor cells
In addition, CD4+ Th1 Cells provide [cytokines](brain://ASLYfJ…
References (Sources)
- Beneficial effects of Bacteroides fragilis polysaccharides on the immune system
- Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice
- Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
- Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88
- Science commentary: Th1 and Th2 responses: what are they?
- The immunology of susceptibility and resistance to Leishmania major in mice
- Tumor Regression and Cure Depends on Sustained Th1 Responses