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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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CD4+ Th1 Cells

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Contents

Phenotypic (constitutively) markers: CD4 +
Stimulating factors: Interleukin-12 (IL-12) , Interleukin-18 (IL-18)
Effector molecules: Interleukin-2 (IL-2) , Interferon Gamma (IFN-g) , Lymphotoxin alfa (LT alfa)

They provide help to B cells for antibody production

Principal function of CD4+ Th1 Cells is to activate macrophages through cytokines (e.g., IFN-gamma) to ingest and kill Microbes / Microorganism and tumor cells
Souza et al., 2013
Dempke et al. 2017 European Journal of Cancer 74: 55e72

In addition, CD4+ Th1 Cells provide [cytokines](brain://ASLYfJ…

References (Sources)

Beneficial effects of Bacteroides fragilis polysaccharides on the immune system
Troy & Kasper 2010
Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice
Seki et al. 2002 Journal of Immunology 169(7): 3863-3868
Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells
Scanga et al. 2002 Journal of Immunology 168(12): 5997-6001
Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88
Fremond et al. 2004 The Journal of Clinical Investigation 114(12): 1790-1799
Science commentary: Th1 and Th2 responses: what are they?
Berger 2000 BMJ 321: 424
The immunology of susceptibility and resistance to Leishmania major in mice
Sacks & Noben-Trauth 2002 Nature Reviews Immunology 2(11): 845-858
Review
Tumor Regression and Cure Depends on Sustained Th1 Responses
Dai et al. 2018 J Immunother. 41(8): 369-378

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