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Two of DNA's four bases, cytosine and Adenines, can be methylated
Methylation of DNA at CpG sites is the most common and stable of epigenetic changes in cancer; in mammals, DNA methylation is almost exclusively found in CpG (CG) dinucleotides, with the cytosines on both strands being usually methylated
Methylation can be used to detect cell death and thereby monitor many common diseases with a simple cell-free circulating-DNA blood test. Some changes in methylation closely correlate with age providing a marker for biological aging, and these same sites could…