meRfi®-GM
Blood vessels
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Contents
Blood vessels play a crucial role in major life-threatening and chronic diseases. Blood vessels are a systemically spread organ. Almost every cell is near a capillary. Endothelial cells line these vessels. They are seen as responsive cells. They react to stimuli like inflammation or cytokines. The vasculature's position is strategic, because it lies between circulation and organ parenchyma. Endothelial cells act as gatekeepers. They control organ function.
Tumor growth and metastasis rely heavily on interactions with blood vessels
Preuss et al. 2023 Physiology (Bethesda) 38: 189-…
References (Sources)
- A systems view of the vascular endothelium in health and disease
- Angiocrine functions of organ-specific endothelial cells
- Milestones in tumor vascularization and its therapeutic targeting
- Role of gut microbiota-derived metabolites on vascular calcification in CKD
- Systemic reprogramming of endothelial cell signaling in metastasis and cachexia