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The presence of Akkermansia muciniphila inversely correlates with body weight in rodents and humans. The abundance of A. muciniphila decreased in obese and type 2 diabetic mice, but prebiotic feeding can normalize its abundance, improving metabolic health. Treatment with A. muciniphila reversed diet-induced metabolic disorders and increased intestinal endocannabinoids, which help control inflammation and gut function. These benefits require live bacteria, as heat-killed cells were ineffective.
Everard et al. 2013 Proc. Natl. Acad. Sci…