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This complex signaling apparatus has more than 100 lipid mediators and 50 proteins, the so-called endocannabinoidome.
The Endocannabinoid System (eCB), which includes cannabinoid receptors, endocannabinoids, and enzymes involved in endocannabinoid metabolism, plays a role in immunoregulation. Manipulation of endocannabinoids can lead to immunosuppression and recovery from immune-mediated injury to organs
Nagarkatti et al. 2009 Future Med Chem. 1(7): 1333-49
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The endocannabinoid system mediates the activity of phytocannabinoids
Endocannabinoids (eCBs) are naturally occurring ligands produced within the body that activate cannabinoid receptors.
BPS/IUPHAR Guide to PHARMACOLOGY
Cannabinoids affect the nervous system and play significant roles in the regulation of the immune system
we identify endocannabinoids as the first known endogenous substrates of the apically restricted multidrug resistance transporter P-glycoprotein (P-gp) (IM)
The eCB system ubiquitously expressed throughout the gut, periphery, and brain is now well recognized to participate in almost all human physiological processes and be involved in several pathological conditions [13-16].
The eCB system has classically been described as a complex pleiotropic system comprised of two cannabinoid responsive G-protein-coupled receptors referred as the eCB receptor type-1 and type-2 (CB 1 and CB 2 ), endogenous lipid-derived ligands for such receptors, known as eCBs, and at least five enzymes responsible for eCB biosynthesis and degradation [23].
The two most studied eCBs are Anandamide (AEA)), also known as anandamide, and 2-arachidonoylglycerol (2-AG)), which belong to the N-acylethanolamine Family (NAEs)) and 2-monoacylglycerol family (2-MAGs)) families, respectively [24].
It is well recognized that eCBs modulate retrograde signaling in the brain, providing a mechanism for inhibitory feedback to regulate neurotransmitter release [32,33].
This unique function of eCBs suggested their investigation as therapeutic targets for human diseases affecting the central nervous system (CNS) [13].
The endocannabinoid system interacts with several nociceptive receptors
The identification of a continuously increasing number of bioactive long-chain fatty acids with Endocannabinoids (eCBs) / The Endocannabinoid System (eCB)-like properties, such as N-palmitoylethanolamine (PEA) / Palmitoylethanolamide and Oleoylethanolamide (OEA), has made it possible to expand the concept of the “endocannabinoidome”
see also:
Cannabinoids & Immunity
Exercise / Physical activity & Gut microbiota