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Interleukin-17D (IL-17D) is a protein expressed in various tissues throughout the body. It plays a crucial role by interacting with CD93, also known as Complement component C1q receptor (C1QR1), on mature Group 3 ILCs (ILC3). This interaction results in an increased release of Interleukin-22 (IL-22) from ILC3, which subsequently leads to the secretion of antimicrobial peptides from Enterocytes or Intestinal Epithelial Cells (IECs). These peptides are e…