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Specific-Pathogen-Free (SPF) Mice are genetically tractable, but unlike adult humans, they exhibit an immunologically naïve phenotype thought to result from limited microbiome and pathogen exposure
When SPF mice are colonized with gut microbiota from pet store mice, there is a notable systemic increase in the numbers of Effector memory T (TEM) / compared to those in conventional laboratory mice. This observation underscores the significant influence that microbial exposure has on the development and function of the immune system.
In Specific-Pathogen-Free (SPF) Mice, commensal microbes are vital. They regulate the s…