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Most of the variance in the human microbiome remains unexplained. Although many individual lifestyles shape the microbiome, significant knowledge gaps persist. Most data on the human microbiome come from individuals in socioeconomically developed countries. This may have skewed the interpretation of microbiome variance and its relationship to health and disease. Furthermore, the striking underrepresentation of minority groups in microbiome studies is a missed opportunity to assess the context, history, and changing nature of the microbiome in relation to disease risk. The variance in the human microbiome is underestimated.
Shana…