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Antigen presentation involves antigen uptake, antigen processing, and antigen loading onto MHC molecules
Sollid & Villadangos, 2013
Long-lived presentation of antigenic protein fragments (called epitopes) required
Antigen Density Presented By DC In Vivo Differentially Affects the Number and Avidity of Primary, Memory, and Recall CD8 + T Cells
Bullock et al., 2003
Only Apoptotic cells and not the necrotic cells were capable of charging Dendritic Cells (DCs) with antigen.
The amounts of specific antigen-MHC complexes on tumors & infected cells are typically small.
The degradation products of phagocytosed debris is shuttled to the endogenous MHC class I presenting system.
Vesicles containing MHC class II intersect with the endocytic pathway and may present peptides derived from pinocytosed proteins.