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Dendritic Cells (DCs)
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Dendritic Cells (DCs) are discovered in 1973 by the Nobel Prize laureate Ralph Steinman. They are present in skin (Langerhans cells), nose, lungs, stomach, intestines.
Dendritic cells (DCs) are professional APCs that effectively prime naïve T cells and differentiate into various functional subsets. In the mucosal tissues, Dendritic Cells (DCs) are predominantly activated and migratory due to the large variety of foreign [Ags](brain://SP0korjM90uXcqiD0tvQtA/AntigenRecognition…
References (Sources)
- DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations
- Dendritic cell regulation of TH1-TH2 development
- Human dendritic cell subsets
- In vivo targeting of human DC-SIGN drastically enhances CD8+ T-cell-mediated protective immunity
- Molecular and Cellular Characterization of Human CD8 T Suppressor Cells
- T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal
- Toll-like receptor signaling mechanisms involved in dendritic cell activation: potential therapeutic control of t cell polarization