meRfi®-GM
Immature DC (iDC) / Langerhans Cells
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Contents
Immature dendritic cells (iDCs), also known as Langerhans cells (LCs), are a specialized subset of antigen-presenting cells (APCs) that play a crucial role in the immune surveillance of the epidermis, the outermost layer of the skin. These cells are strategically positioned to act as immune sentinels, capturing antigens at the skin barrier and migrating to lymph nodes to prime T- and B-lymphocytes, leading to a variety of immune responses
Langerhans cells have been shown to be capable of inducing the proliferation of skin-resident CD8 memory T cells, which are …
References (Sources)
- Antigen-bearing immature dendritic cells induce peptide-specific CD8 Treg in vivo in humans
- CSF1R Is Required for Differentiation and Migration of Langerhans Cells and Langerhans Cell Histiocytosis
- Epidermal Langerhans cells are derived from cells originating in bone marrow
- Epidermal Langerhans Cells bear Fc and C3 receptors
- Ia antigens in mouse skin are predominantly expressed on Langerhans Cells
- Langerhans Cells-Revising Their Role in Skin Pathologies
- Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays