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Antigen presentation
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Contents
Antigen presentation involves antigen uptake, antigen processing, and antigen loading onto MHC molecules
Sollid & Villadangos, 2013
Long-lived presentation of antigenic protein fragments (called epitopes) required
Antigen Density Presented By DC In Vivo Differentially Affects the Number and Avidity of Primary, Memory, and Recall CD8 + T Cells
Bullock et al., 2003
Only Apoptotic cells and not the necrotic cells were capable of charging Dendritic Cells (DCs) with antigen.
The amounts of specific antigen-MHC complexes on tumors & infected cells are typically small.
The degradation product…
References (Sources)
- Antigen processing
- CD1: Antigen Presentation and T Cell FunctionReview
- Class discrimination in the world of immunology
- Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTL
- Dendritic cells and the control of immunity
- Identification of an epitope from the epithelial cell adhesion molecule eliciting HLA-A*2402 restricted CTL responses
- Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines