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Gasdermins
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The gasdermin family of cell death executor proteins are activated by different proteases under different physiological conditions. A recent study by Deng et al. in Nature revealed that the cysteine protease Streptococcal pyrogenic exotoxin B (SpeB) from the human pathogen Streptococcus pyogenes directly cleaves and activates Gasdermin A (GSDMA) to induce pyroptosis in skin cells
Gasdermin proteins are in fungi an…
References (Sources)
- Bacterial gasdermins reveal an ancient mechanism of cell death
- CARD-like domains mediate anti-phage defense in bacterial gasdermin systems
- Fungal gasdermin-like proteins are controlled by proteolytic cleavage
- Molecular characterization of a fungal gasdermin-like protein
- Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
- Structure and assembly of a bacterial gasdermin pore