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Pyroptosis
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Contents
Pyroptosis is a highly inflammatory form of programmed cell death distinct from apoptosis. It is characterized by cell swelling, membrane rupture, and the release of pro-inflammatory cellular contents.
Pyroptosis is mediated by the activation caspase-1 in response to various infection or stress signals. It is associated with the construction and activation of the NLRP3 inflammasome.
see also:
Caspase Recruitment Domains (CARDs)
[Caspases & Pyroptosis](brain://FaJuNTbyPUelbduS0uzX6g/CaspasesPyropt…
References (Sources)
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis
- Pyroptosis: gasdermin-mediated programmed necrotic cell death
- Pyroptosis: mechanisms and diseases
- Pyroptotic death storms and cytopeniaReview
- Role of pyroptosis in inflammation and cancer