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Caspase Recruitment Domains (CARDs)
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Contents
NOD-like receptors (NLRs) come together to form oligomers and connect with adaptor proteins that contain a caspase-recruitment domain (CARD). This domain is a short module responsible for protein-protein interactions, which facilitates the recruitment of Inflammatory Caspases (group I caspases).
In the process of recruitment and activation, caspases remove the C-terminal repressor domain from gasdermins. This action rele…
References (Sources)
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
- Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
- Pore-forming activity and structural autoinhibition of the gasdermin family
- The PYRIN-CARD protein ASC is an activating adaptor for caspase-1