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Inflammatory Caspases (group I caspases)
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Inflammatory caspases are involved in the regulation of inflammatory responses and the maturation of pro-inflammatory cytokines
In mammals, these caspases are characterized by the presence of a Caspase Recruitment Domains (CARDs) at the N-terminus. The caspases are called 'inflammatory' because the primary substrates of caspase-1 identified so far are Pro-Interleukin-1 (IL-1) beta (IL-1 beta) and Pro-Interleukin-18 (pro-IL-18), which are two re…