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Activated Caspase-1 / Interleukin-1 Converting Enzyme (ICE) processes the cytosolic precursors of the related cytokines interleukin-1 beta, IL-18, and Interleukin-33 (IL-33) thus allowing secretion of the biologically active cytokines
The formation of the NLRP3 inflammasome triggers the self-proteolytic activation of Caspase-1 / Interleukin-1 Converting Enzyme (ICE). Caspase-1 cleaves cell substrates such as [Pro-Interleukin-1 beta (pro-IL1 bet…