meRfi®-GM
Caspase-1 / Interleukin-1 Converting Enzyme (ICE)
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Contents
Activated Caspase-1 / Interleukin-1 Converting Enzyme (ICE) processes the cytosolic precursors of the related cytokines interleukin-1 beta, IL-18, and Interleukin-33 (IL-33) thus allowing secretion of the biologically active cytokines
The formation of the NLRP3 inflammasome triggers the self-proteolytic activation of Caspase-1 / Interleukin-1 Converting Enzyme (ICE). Caspase-1 cleaves cell substrates such as [Pro-Interleukin-1 beta (pro-IL1 bet…
References (Sources)
- A pre-aspartate-specific protease from human leukocytes that cleaves pro-interleukin-1 beta
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
- ldentification of a monocyte specific pre-Interleukin-1 beta convertase activity
- Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developrnents
- Serum caspase-1 levels in metastatic melanoma patients: relationship with tumour burden and nonresponse to biochemotherapy
- The C. elegans cell death gene cd-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme