meRfi®-GM
Interleukin-1 (IL-1) beta (IL-1F2)
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Contents
Interleukin-1 (IL-1) beta (IL-1F2) is primarily produced by phagocytes in response to MAMPs that induce transcription of IL-1beta mRNA, whereas inflammasomes promote proteolytic activation of IL-1beta and assembly of gasdermin pores, facilitating non-canonical secretion of the active cytokine and induction of pyroptosis
IL-1 is required for tum…
References (Sources)
- Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages
- Dendritic Cells Use Macropinocytosis and the Mannose Receptor to Concentrate Macromolecules in the Major Histocompatibility Complex Class II Compartment: Downregulation by Cytokines and Bacterial Products
- IL-1 is required for tumor invasiveness and angiogenesis
- IL-1ß Enhances CD40 Ligand-Mediated Cytokine Secretion by Human DC: A Mechanism for T Cell-Independent DC Activation
- IL-1ß Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells
- Innate and adaptive effects of inflammasomes on T cell response
- The MDM2-p53 pathway revisited