Interleukin-17 Family / Interleukin-17 (IL-17)

Interleukin-17 (IL-17), a pro-inflammatory cytokine, plays a crucial role in mediating inflammatory and immune responses.

Interleukin-17 (IL-17) plays a dual role, mediating protective innate immunity against pathogens and contributing to the pathogenesis of inflammatory diseases like psoriasis and rheumatoid arthritis
Zenobia & Hajishengallis 2015 Periodontol 2000 69(1): 142-59

In most contexts, especially clinical and research settings, IL-17 and IL-17A are used synonymously. However, when precision is required, such as in genetic studies or when discussing specific cytokine family members, the term IL-17A is preferred to avoid ambiguity
Abdellah et al. 2023 Egypt J Immunol 30(3): 134-147
Coste et al. 2024 Biomedicines 12(9): 2144

A deficiency in either Interleukin-17 (IL-17) or Interleukin-22 (IL-22), which are part of the Interleukin-17 Family, can be deadly in certain infections. Interleukin-22 plays a crucial role in the initial defense of the host against bacterial pathogens that attach and efface.
Mangan et al. 2006 Nature 441: 231-234
Zheng et al. 2008 Nat Med 14: 282-289

Interleukin-17 (IL-17) Molecular Target/Signaling

through the IL-17RA–IL-17RC complex and activate the NFKB and MAPK pathways
Gaffen 2009 Nat Rev Immunol 9(8): 556-67

see also:
Carcinogenesis / Oncogenesis / Tumorigenesis & Interleukin-17 Family / Interleukin-17 (IL-17)
Inflammatory Bowel Disease (IBD) & Interleukin 17 Family / Interleukin-17 (IL-17)
Interleukin-17 (IL-17) / Interleukin-23 (IL-23) Axis
Interleukin-17 Family / Interleukin-17 (IL-17) & Members
IL-17A-producing cells
Interleukin-17 (IL-17) / IL-17A (mCTLA-8) Production