Carcinogenesis / Oncogenesis / Tumorigenesis & Interleukin-17 Family / Interleukin-17 (IL-17)

Interleukin-17A (IL-17A) induces the recruitment and activation of granulocytes and locally promotes the production of other pro-inflammatory cytokines such as TNF-alfa, IL-6, and IL-1 beta
Kasama et al. 2000 Clin Exp Immunol 121(3): 533-8
Iwakura et al. 2011 Immunity 34(2): 149-62

In line with these findings, a blockade of IL-23 and Interleukin-21 (IL-21) in murine models of colitis results in decreased numbers of CD4+ Th17 cells(brain://KDvE1Ok65EOQS0YdWsP-vw/THelper17Cell) and in a favorable disease outcome
Fina et al. 2008 Gastroenterology 134: 1038–48
Maxwell et al. 2015 Immunity 43(4): 739-50

Following a barrier defect, Bacterial Translocation / Intestinal permeability and IL-23 production by innate immune cells, such as DCs and macrophages, induce high levels of Interleukin-17A (IL-17A) which in turn can favor intestinal tumorigenesis
Grivennikov et al. 2012 Nature 491(7423): 254-258

see also:
Biological effects / Functions & Interleukin-17 Family / Interleukin-17 (IL-17)
Cancer / Tumors & Interleukin-1 (IL-1) / Interleukin-1 family
Carcinogenesis / Oncogenesis / Tumorigenesis & Immunity
Carcinogenesis / Oncogenesis / Tumorigenesis & Interleukin-23 (IL-23)
Interleukin-17 (IL-17) / Interleukin-23 (IL-23) Axis
XXX - Lactobacillus helveticus NS8 & Colitis-associated colorectal cancer (CAC)