Inflammatory Bowel Disease (IBD) & Interleukin 17 Family / Interleukin-17 (IL-17)

Because of co-expressing interferon-gamma and interleukin-17A, CD4+ Th17 cells with pathogenicity are named pathogenic T helper 17 cell (Th17)
Cao et al. 2023a Inflammatory Bowel Diseases 29(5): 818-829

Studies have shown that Interleukin-17 Family / Interleukin-17 (IL-17) expression is upregulated in Inflammatory Bowel Disease (IBD) patients. In Crohn's disease (CD), colonic IL-17F mRNA expression was found to be 4.4-fold higher in inflamed lesions compared to uninflamed biopsies. The mean intestinal IL-17F mRNA expression was observed to be higher in ulcerative colitis (UC) than in Crohn's disease (CD).
Seiderer et al. 2008 Inflamm Bowel Dis. 14(4): 437-45

Interleukin-23 (IL-23) amplifies T helper 17 cell (Th17) responses and gut inflammation
Sarra et al. 2010 Inflamm Bowel Dis 16(10): 1808-13

Interleukin 17 Family / Interleukin-17 (IL-17) promotes the production of pro-inflammatory cytokines and chemokines.
It enhances neutrophil recruitment to inflamed tissues and stimulates the release of matrix metalloproteinases, which can lead to tissue damage
Sarra et al. 2010 Inflamm Bowel Dis 16(10): 1808-13

see also:
Biological effects / Functions & Interleukin-17 Family / Interleukin-17 (IL-17)
Colitis / Intestinal Inflammation & Interleukin-23 (IL-23)
High-salt diet & Inflammatory Bowel Disease (IBD)
Inflammatory Bowel Disease (IBD) & Interleukin-12 (IL-12)
CD4+ Th17 cells