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Genes for colibactin (clbB) and Bacteroides fragilis toxin (bft), which encode secreted oncotoxins, were highly enriched in the colonic mucosa of Familial Adenomatous Polyposis (FAP) patients compared to healthy individuals.
Tumor-prone mice cocolonized with Colibactin-Producing Escherichia coli / E. coli pks+ and enterotoxigenic B. fragilis showed: