meRfi®-GM
Tumor-associated macrophages (TAMs) & Tumor microenvironment (TME)
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Glucose enters tumor cells via Glucose transporter 1 (GLUT1) and generates pyruvate via glycolysis, which is further converted to lactate via Lactate dehydrogenase A (LDHA). Intracellular lactate is transported into the Tumor Microenvironment (TME) via [SLC16A3 / Monocarboxyla…