meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Butyrate / Butyric acid & Regulatory T Cells (Tregs)
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Contents
Among short-chain fatty acids, butyrate induced the differentiation of functional colonic Treg cells in vitro and in vivo in mice via epigenetic upregulation of the foxp3 gene
DCs exposed to butyrate promote conversion of naïve T cells into immunosuppressive [RAR-related Orphan Receptor Gamma/T (ROR-gamma/t) Isoform 2 (NR1F3)t + Foxp…
References (Sources)
- Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
- Emerging Frontiers in Microbiome EngineeringReview
- Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
- Short chain fatty acids (SCFAs) mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases
- Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and CRC under low-fibre dietary conditions
- The gut microbiome in health and in disease
- The microbial metabolites, short chain fatty acids, regulate colonic Treg cell homeostasis