meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Diseases / Disorders & Microbial Metabolites
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Contents
Microbial-derived metabolites (e.g., secondary bile acids, TMAO, Tryptophan & Derivatives) produced in the gut can cross the intestinal epithelial barrier, enter the systemic circulation, and trigger physiological responses, directly and indirectly, affecting the central nervous system and its functions.
Important representatives of gut bacteria metabolites are bile acids.
Cai et al. 2022 Cell Host & M…
References (Sources)
- Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential
- Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women
- Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome
- Indole and tryptophan metabolism: endogenous and dietary routes to Ah Receptor Activation
- Indoles from commensal bacteria extend healthspan
- Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
- Microbially produced imidazole propionate impairs insulin signaling through mTORC1