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Microbial-derived metabolites (e.g., secondary bile acids, TMAO, Tryptophan & Derivatives) produced in the gut can cross the intestinal epithelial barrier, enter the systemic circulation, and trigger physiological responses, directly and indirectly, affecting the central nervous system and its functions.
Important representatives of gut bacteria metabolites are bile acids.
Cai et al. 2022 Cell Host & M…