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IL-25 produced by tuft cells induces IL-13 production by ILC2s in the lamina propria; In the intestine tuft cells are the sole source of secreted IL-25
Intestinal tuft cells expand rapidly in response to pathogenic infections, associated with infection-induced upregulation of interleukin 25 (IL-25) production.
For example, enteroviruses such as EV71, CVA16, CVB3, and CVB4 upregulated IL-25 expression a…