meRfi®-GM
Interleukin-17E (IL-17E) / Interleukin-25 (IL-25) & Tuft Cells
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Contents
IL-25 produced by tuft cells induces IL-13 production by ILC2s in the lamina propria; In the intestine tuft cells are the sole source of secreted IL-25
Intestinal tuft cells expand rapidly in response to pathogenic infections, associated with infection-induced upregulation of interleukin 25 (IL-25) production.
For example, enteroviruses such as EV71, CVA16, CVB3, and CVB4 upregulated IL-25 expression a…
References (Sources)
- A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling.
- Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine.
- Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit.
- Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis
- Folate supports IL-25-induced tuft cell expansion following enteroviral infections
- The intestinal epithelium tuft cells: specification and function
- Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut